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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Chem Rev. 2014 Mar 3;114(7):3659–3853. doi: 10.1021/cr400327t

Table 19.

Primary Deuterium isotope effects on steady-state parameters

Enzyme (Substrate) D(Vmax) or
Dkcat		 D(Vmax/Km)
substrate
PHM (hippuric acid)580,586 1.56 ~ 3.9
DβM (dopamine)587 1.00 ~ 3.7
TβM (tyramine)534 2.7 ~ 2.0