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. Author manuscript; available in PMC: 2015 Apr 9.
Published in final edited form as: Chem Rev. 2014 Mar 3;114(7):3659–3853. doi: 10.1021/cr400327t

Table 38.

Crystal structures of processed copper amine oxidases deposited in the Protein Data Bank as of October 10, 2012.

Perturbation Source
Organism		 Coordination
Sphere		 TPQ State Resolution
(Å)		 PDB
ID
Native Active
---1193 E. coli 3His, H2O quinone 2.0 1dyu
---1194 A. globiformis 3His, H2O quinone 2.3 1av4
anaerobically Cu loaded exposed to O2 1195 A. globiformis 3His, H2O quinone 2.2 1ivx
---1196 A. globiformis 3His, H2O quinone 2.2 1w6c
---1197 H. polymorpha 3His, 2H2O quinone 2.4 1a2v
---1198 H. polymorpha 3His, 2H2O quinone 2.0 3loy
---1199 P. sativum 3His, 2H2O quinone 2.2 1ksi
---1200 H. sapiens 3His, H2O quinone 2.5 2c10
---1201 H. sapiens 3His, H2O quinone 2.95 2y74
---1202 H. sapiens 3His quinone 2.9 3ala
---1203 B. taurus 3His, H2O quinone 2.37 1tu5
---1204 A. nidulans 3His, H2O quinone 2.45 3pgb
Native Inactive
---1147 E. coli 3His, TPQ quinone 2.0 1oac
EDTA treated1205 E. coli 3His, TPQ quinone 2.6 2wo0
EDTA treated1205 E. coli 3His, TPQ quinone 2.25 2wof
---1194 A. globiformis 3His, TPQ
His592 disordered		 quinone 2.8 1avl
anaerobically Cu loaded exposed to O2 1195 A. globiformis 3His, TPQ quinone 1.9 1ivw
---1196 A. globiformis 3His, TPQ, H2O quinone 1.55 1w6g
---1206 H. polymorpha 3His, TPQ, H2O quinone 1.7 2oov
---1207 P. pastoris 3His, TPQ quinone 1.23 1w7c
---1208 P. pastoris 3His, TPQ quinone 1.65 1n9e
---1209 H. sapiens 3His, TPQ quinone 2.9 1us1
---1209 H. sapiens 3His, TPQ quinone 3.2 1pu4
---1201 H. sapiens 3His, TPQ quinone 2.6 2y73
---1210 H. sapiens 3His, TPQ quinone 2.11 3k5t
---1211 H. sapiens 3His, TPQ quinone 1.8 3hi7
Variants
H433A1188 A. globiformis 2His, Tyr, H2O Tyr 2.0 1ui7
H592A1188 A. globiformis 2His, bidentate TPQ quinone 1.8 1ui8
Y305A1190 H. polymorpha 3His, H2O quinone 2.5 3n9h
Y369F1212 E. coli 3His, 2H2O quinone 2.1 1jrq
D383A1193 E. coli 3His, TPQ quinone 2.0 1qak
D383E1193 E. coli 3His, 2H2O quinone 2.2 1qaf
D383N1193 E. coli 3His, H2O quinone 2.2 1qak
D298A1213 A. globiformis 3His, H2O quinone 1.82 2cwt
Substrate-reduced
anaerobically substrate reduced1214 E. coli 3His, H2O aminoquinol 2.4 1d6u
anaerobically substrate reduced + NO1214 E. coli 3His, NO aminoquinol 2.4 1d6y
Substrate-bound
2-hydraxinopyridine1214 E. coli 3His, H2O Schiff base 2.0 1spu
ethylamine1215 A. globiformis 3His, H2O Schiff base 1.73 2zl8
5-phenoxy-2,3-pentadienylamine1216 A. globiformis 3His, H2O Schiff base 1.9 3kii
6-phenyl-2,3-hexdienylamine1216 A. globiformis 3His, H2O Schiff base 2.05 3kn4
D298A + 2PEA 1213 A. globiformis 3His, H2O Schiff base 1.85 2cwu
D298A + tyramine1217 A. globiformis 3His, 2H2O Schiff base 1.74 2d1w
Inhibitor Complexes
tranylcypromine1218 E. coli 3His, H2O Schiff base 2.4 1lvn
tranylcypromine1219 A. globiformis 3His, 2H2O Schiff base 1.65 1w4n
phenylhydrazine1220 A. globiformis 3His, 2H2O hydrazone 2.05 2e2t
benzylhydrazine1219 A. globiformis 3His, 2H2O hydrazone 1.86 1w5z
benzylhydrazine1220 A. globiformis 3His, 2H2O hydrazone 1.80 2e2v
4-hydroxybenzylhydrazine1220 A. globiformis 3His, H2O hydrazone 1.68 2e2u
MOBA1221 A. globiformis 3His, H2O Schiff base 1.73 1sih
NOBA1221 A. globiformis 3His Schiff base 1.70 1sii
Ru C4-racemic wire1222 A. globiformis 3His, 2H2O quinone 1.73 2bt3
Ru C4-lambda wire1223 A. globiformis 3His, H2O quinone 1.60 2cfd
Ru C4-delta wire1223 A. globiformis 3His, H2O quinone 1.55 2cfg
Ru C5 wire1223 A. globiformis 3His, 2H2O quinone 1.8 2cfk
Ru C6 wire1223 A. globiformis 3His, 2H2O quinone 1.8 2cfl
Ru C7 wire1223 A. globiformis 3His, 2H2O quinone 1.74 2cfw
Ru C9 wire1223 A. globiformis 3His, 2H2O quinone 1.8 2cg0
Ru C11 wire1223 A. globiformis 3His, 2H2O quinone 1.67 2cg1
2-hydrazinopyradine1200 H. sapiens 3His, H2O hydrazone 2.9 2c11
aminoguanidine1211 H. sapiens 3His, H2O Schiff base 2.05 3mph
berenil1211 H. sapiens 3His, TPQ quinone 2.09 3hig
pentamidine1211 H. sapiens 3His, TPQ quinone 2.15 3hii
clonidine1224 B. taurus 3His, TPQ quinone 2.4 2pnc
Trapped Catalytic Intermediates
aerobically trapped O2 equilibrium species1225 E. coli 3His aminoquinol 2.1 1d6z
time-resolved X-ray structure1226 A. globiformis 3His, H2O Schiff base 2.1 3amo
Alternative Metal Substituted
Co-substituted1191 A. globiformis 3His, 3H2O quinone 1.8 1wmn
Co-substituted1227 A. globiformis 3His, 3H2O quinone 2.0 1iqx
Ni-substituted1191 A. globiformis 3His, 3H2O quinone 1.8 1iqy
Ni-substituted1227 A. globiformis 3His, 3H2O quinone 1.8 1wmo
Sr soaked1205 E. coli 3His, H2O quinone 2.7 2woh
Xe Complexes
Xe complex1206 H. polymorpha 3His quinone 1.6 2oqe
Xe complex1228 A. globiformis 3His, H2O quinone 1.67 1rjo
Xe complex1228 P. sativum 3His, H2O quinone 2.24 1w2z
Xe complex1228 P. pastoris 3His, TPQ quinone 1.68 1rky
Xe complex1229 E. coli 3His, H2O quinone 2.48 2w0q