. Author manuscript; available in PMC: 2015 Apr 9.

Published in final edited form as: Chem Rev. 2014 Mar 3;114(7):3659–3853. doi: 10.1021/cr400327t

Table 39.

X-ray crystal structures of apo, preprocessed, metal-substituted and mutant copper amine oxidase varients relevant to TPQ biogenesis.

Perturbation	Source Organism	Coordination Sphere	TPQ State	Resolution (Å)	PDB ID
apo¹¹⁹⁴	A. globiformis	---	Tyr	2.2	1avk
apo¹²³⁰	H. polymorpha	---	Tyr	1.73	3sx1
anaerobically Cu loaded¹¹⁹⁵	A. globiformis	3His, Tyr at 2.58 Å His592 disordered	Tyr	1.9	1ivu
anaerobically Cu loaded + O₂ ¹¹⁹⁵	A. globiformis	3His, H₂O, DPQ His592 disordered	DPQ	2.1	1ivv
Zn-substituted¹²³¹	H. polymorpha	3His, Tyr at 2.02 Å	Tyr	2.5	1ekm
Zn-substituted¹²³²	E. coli	3His, Tyr at 1.87 Å	Tyr	2.5	2wgq
Co-substituted¹²³⁰	H. polymorpha	3His, Tyr at 2.19 Å H₂O	Tyr	1.27	3sxx
Co-substituted¹¹⁹¹	A. globiformis	3His	Tyr	2.0	1wmp
Cu^I-substituted¹²³⁰	H. polymorpha	3His, Tyr at 2.8 Å	Tyr	1.90	3tou
Y305F¹¹⁹⁰	H. polymorpha	3His, quinone	peroxy-quinone	2.05	3nbb
Y305F¹¹⁹⁰	H. polymorpha	3His	peroxy-quinone	1.9	3nbj
D298K¹²³³	A. globiformis	3His, H₂O	Schiff base	1.68	2yx9