. Author manuscript; available in PMC: 2015 Apr 9.

Published in final edited form as: Chem Rev. 2014 Mar 3;114(7):3659–3853. doi: 10.1021/cr400327t

Table 8.

Site-site interaction energy δ(ΔG) from model fits to oxygen binding data.

Arthropod

Organism	$P_{1 / 2}^{T}$ (torr)^a	$P_{1 / 2}^{R}$ (torr)^a	δ(ΔG) (kcal/mol)	T (°C)	P_1/2 (torr)	n_H	Heterotrophic Affectors	Model
Crab
Callinectes sapidus²⁰⁶	160 to 450	0.3 to 7.9	−2.3 to −3.6	20	4 to 75	2.7 to 4.7	Ca²⁺, Cl⁻, H⁺	TS^c
Cancer magister²⁰⁷	320 to 14	1.2 to 1.8	−1.2 to −3.2	15	5 to 57	1.1 to 3.4	Dopamine	MWC^b
Carcinus aestuarii²⁰⁸	25 to 170	0.5 to 4.0	−2.2	20	6.8 to 44	3.1 to 3.9	Ca²⁺, Cl⁻, H⁺	MWC^b
Carcinus maenas²⁰⁹
Ocypoda cursor²¹⁰	280	74	−0.8	20	130	2.0	---	MWC^b
Pagurus bernhardus¹⁷³	410	3	−2.8	15	22 to 230	2.5–3.7	whole blood, H⁺	MWC^b
Scylla serrate²¹¹	33	0.27	−2.8	25	11	---	Ca²⁺, Cl⁻	TS^c
Telphusa fluviatilis²¹⁰	100	14	−1.2	20	49	2.6	---	MWC^b
Insect
Pachnoda marginata¹⁵¹	16	1.6	−1.3	20	8	2	---	MWC^b
Lobster
Homarus americanus²¹¹	160	1.3	−2.9	25	91	---	Ca²⁺, Cl⁻	TS^c
Homarus vulgaris²¹²	125	0.6	−3.2	25	6 to 95	3.7 to 4.4	urate, H⁺	N^d
Panulirus interruptus¹⁹⁹	9.6	1.25	−1.2	20	3.5	2.3	Ca²⁺	MWC^b
Panulirus japonicas²¹³	13	2.3	−1.0	25	5	3.2	---	MWC^b
Scorpion
Leirus quinquestriatus²¹⁰	100	1.3	−2.5	20	14	6.8	---	MWC^b
Pandinus imperator²¹⁴	72	0.3	−3.3	20	4 to 13	5.4 to 6.5	Ca²⁺, Mg²⁺, Cl⁻, H⁺	N^d
Shrimp
Callianassa californiensis¹⁹⁸	170	0.6	−3.4	25	2.4 to 132	1.1 to 3.6	Mg²⁺, Ca²⁺, H⁺, Cl⁻	MWC^b
Penaeus setiferus²¹⁵	500	0.1	−5.0	20	0.3 to 112	2.2 to 4.2	Ca²⁺, H⁺	MWC^b
Upogebia pusilla²¹⁶	29	0.1	−3.3	20	0.8 to 19	1.8 to 4.2	H⁺, L-lactate	TS^c
Spider
Eurypelma californicum¹⁹⁷	278	0.4	−3.9	25	3.6 to 33	2 to 7	H⁺	MWC^b
Molluse

Organism	$P_{1 / 2}^{T}$ (torr)^a	$P_{1 / 2}^{R}$ (torr)^a	δ(ΔG) (kcal/mol)	T (°C)	P_1/2 (torr)	n_H	Heterotrophic Affectors	Model

Octopus
Octopus doflini¹⁸⁸	4 to 280	1 to11	−0.6 to −2.2	20	5 to 360	1.9 to 3.3	saline, H⁺	TS^c
Snail
Haliotis iris¹⁹⁴	13	2.2	−1.0	15	8.9	3.3	Mg²⁺, Cl	MWC^b
Hexaplex trunculus²¹⁷	42	2	−1.8	20	2.8 to 28	1.3 to 4.0	Ca²⁺, Cl	MWC^b
Levantina hierosolima²¹⁸	11–25	1.9 to 5.0	−0.5 to −1.5	25	7 to 12	>1	Ca²⁺, Cl	MWC^b
Lymnaea stagnalis²⁰³	7.8 to 15.5	0.8 to 5.1	−0.6 to −1.8	20	2.0 to 7.2	2.0 to 8.6	Ca²⁺, Cl	MWC^b
Squid
Sepioteuthis lessoniana²¹⁹	65	4.1	−1.6	20	15	2.4	Mg²⁺	MWC^b

For models with more than one state, the highest affinity state is $P_{1 / 2}^{T}$ and the lowest affinity state is $P_{1 / 2}^{R}$ .

Monod, Wyman, Changeux Model

Three State MWC Model

Nested Model