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A 52-year old male with a history betel quid chewing presented with submucous fibrosis involving bilateral buccal mucosa (A). Autofluorescence visualization showed enhanced fluorescence of the affected mucosa except for the erythematous area revealing loss of fluorescence (B). An incisional biopsy taken from the area with the loss of fluorescence revealed the presence of superficially invasive squamous cell carcinoma.
