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HPV associated squamous cell carcinoma. (A) Low power view of the tumor arising in the tonsillar cryptic mucosa (arrow) deep to the surface mucosa, (B) Higher power of monotonous, non-keratinizing neoplastic cells typical of this phenotype, (C) Strong/over-expressed p16 immunohistochemical staining throughout the tumor, (D) HPV positive in situ hybridization staining of the tumor nuclei (arrow)
