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. Author manuscript; available in PMC: 2015 May 25.
Published in final edited form as: Mol Cell Endocrinol. 2014 Jan 11;389(0):40–47. doi: 10.1016/j.mce.2013.12.017

Table 1.

EC50 (IC50) values for non-feminizing estrogen analogues.

Reproduced from Yi et al., 2011 with permission.

Compound Glut
(10 mM)		 Glut
(20 mM)		 IAA
(20 µM)		 IAA
(40 µM)		 Erα
Binding		 Erβ
Binding		 TBARs Compound Glut
(10 mM)		 Glut
(20 mM)		 IAA
(20 µM)		 IAA
(40 µM)		 ERα
Binding		 ERβ
Binding		 TBARs
ZYC1 1.025 1.571 0.253 1.72 3.978 4.058 4.922 ZYC41 11.30 1.573 1.341 34.27 105.0 6.291
ZYC2 9.021 10.00 0.006 8.259 126.75 165.8 16.075 ZYC42 1.167 1.510 0.051 0.942 248.5 323.6 21.89
ZYC3 0.159 0.365 0.216 10000 10000 1.126 ZYC43 0.730 1.511 1.393 1.449 8729 7938 4.506
ZYC4 9.207 17.14 196.2 0.052 43.57 31.41 10.171 ZYC44 0.363 0.399 0.051 0.167 2637.5 10000 0.408
ZYC5 0.023 0.121 0.120 0.152 10000 10000 1.391 ZYC45 0.684 0.975 0.239 0.446 800.2 5176 2.214
ZYC6 17.61 13.69 2.708 8.483 1698 10000 17.079 ZYC46 0.866 0.465 0.069 0.155 7305 10000 2.130
ZYC7 8.582 14.73 2.405 1.729 133.5 242.1 5.332 ZYC47 0.139 0.121 0.017 0.088 8831 10000 1.415
ZYC9 1.956 1.315 5.020 5.296 480.65 204.2 29.465 ZYC48 0.179 0.527 0.176 1.599 877.5 5208 3.120
ZYC10 0.488 0.851 0.296 0.679 16.32 8.138 3.132 ZYC49 NP NP NP NP 10000 10000 NI
ZYC11 4.627 7.031 0.296 0.679 107.0 64.49 26.115 ZYC50 0.111 0.139 0.081 0.235 202.7 769.2 2.156
ZYC12 0.548 1.953 1.290 4.440 73.96 53.35 4.763 ZYC51 0.653 1.769 0.446 0.651 1649 4702 1.521
ZYC13 0.239 1.173 0.191 0.129 25.30 18.70 9.167 ZYC52 2.439 4.101 0.057 0.286 4258 114.3 16.59
ZYC14 0.215 0.240 0.183 0.382 2263 2461 1.033 ZYC53 14.68 143.2 0.072 0.375 10000 10000 NI
ZYC15 0.047 0.803 0.646 1.200 1649 10000 1.495 ZYC54 5.138 7.621 0.210 0.918 10000 10000 1.580
ZYC16 0.882 0.860 2.250 1.912 10000 10000 3.648 ZYC55 0.913 0.926 0.246 0.458 10000 10000 1.369
ZYC17 0.244 0.270 0.680 0.828 10000 10000 4.913 ZYC56 3.550 4.59 0.313 1.717 445.3 354.1 18.60
ZYC18 0.568 0.921 0.264 1.044 2384.5 10000 2.307 ZYC57 NP NP 0.165 1.311 593.9 10000 20.19
ZYC19 0.184 0.272 0.099 0.302 784.1 10000 2.488 ZYC58 1.655 2.922 0.163 0.829 10000 10000 2.564
ZYC20 0.132 0.273 0.908 1.134 5089 10000 1.905 ZYC59 0.765 0.924 0.162 0.337 752.6 263.9 7.398
ZYC21 0.122 0.245 0.108 0.282 2855 4456 1.264 αE2 3.102 5.739 3.375 161.7 16.46 83.75
ZYC22 0.030 .030 0.084 0.358 10000 10000 1.827 βE2 1.364 1.978 2.902 4.704 3.041 4.512 19.83
ZYC23 NP NP NP NP 10000 10000 NI DES 3.772 14.10 0.769 3.802 2.615 1.84 6.882
ZYC24 0.665 0.768 1.132 3.928 209.45 259.95 7.028 E1 3.029 8.920 2.092 1609.2 13.35 30.92 80.79
ZYC25 0.238 0.147 0.159 0.359 10000 10000 1.375 E1-quinol 10000 10000
ZYC26 0.012 0.037 0.164 0.280 10000 10000 0.708 EntE2 0.936 1.166 7.110 35.01 24.65 5.635 23.95
ZYC27 0.992 1.195 0.541 1.932 14.28 11.97 3.279 E380 1.277 1.980 0.159 1.230 5.912 2.372 6.725
ZYC28 0.497 0.568 0.458 1.268 61.12 533.9 7.88 E400 1.651 1.866 0.126 1.245 117.5 52.37 20.88
ZYC29 6.730 8.252 1.576 7.525 10.97 17.42 10.47 E430 NP NP 7.923 33.47 1880 10000 NI
ZYC30 8.290 9.033 0.591 8.814 26.95 16.84 14.89 E1240 NP NP NP NP 785.5 1197 NI
ZYC33 0.0938 0.1273 0.046 0.086 10000 10000 1.208 E2540 NP NP NP NP NI
ZYC34 0.121 0.19 0.046 0.219 1460 88.01 0.664 E2550 NP NP NP NP 953.4 260.3 NI
ZYC35 3.203 3.896 1.021 1.623 5.53 14.31 7.806 E2555 NP NP NP NP 1513 10000 NI
ZYC36 6.883 6.627 1.195 N/A 5.55 2.64 17.445 E2560 NP NP NP NP 33.06 261.7 NI
ZYC37 11.75 8.228 1.836 4.25 4.88 7.48 11.024 PS1 13.08 13.84 17.45 2.547 29.04 12.22 9.701
ZYC38 0.133 0.213 0.021 0.035 296.4 10000 0.895 PS2 10.15 16.21 278.7 1662 27.65 33.09 8.951
ZYC39 0.180 0.368 0.049 0.282 633.2 10000 1.577 PS3 NP NP NP NP 692.2 615.4 NI
NYC40 0.524 0.443 1.901 PS4 NP NP NP NP 2862 10000 NI

NP (no protection); NI (no inhibition); 10000 (over 10 µM required for binding or no binding activity).