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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Int J Parasitol. 2014 Jan 31;44(0):251–261. doi: 10.1016/j.ijpara.2013.12.003

Fig. 3.

Fig. 3

Phylogenetic tree. The relationships of type 2-like cystatins of Dictyocaulus filaria (Df-CPI) and Dictyocaulus viviparus (Dv-CPI) compared with other nematodes, including proteins with a role in immunomodulation (bold) (see Table 3). A red square represents a sequence that possesses an SND/SNS C13 legumain-like asparaginyl endopeptidase (AEP)-binding loop motif. An asterisk represents a sequence that lacks one or more conserved motifs essential for the binding of C1 papain peptidase (Gregory and Maizels, 2008). An “X” represents a sequence that lacks a signal peptide. The clusters A–C shaded) and branches a–c are indicated. Posterior probabilities (pp) are indicated at key nodes. AEP, asparaginyl endopeptidase inhibitor domain; PW, C-terminus C1 papain-like peptidase binding domain; Ac, Ancylostoma caninum; As, Ascaris suum; Ava, Angiostrongylus vasorum; Avi, Acanthocheilonema viteae; Bm, Brugia malayi; Ce, Caenorhabditis elegans; Di, Dirofilaria immitis; Hb, Heterorhabditis bacteriophora; Hc, Haemonchus contortus; Hp, Heligmosomoides polygyrus; Ll, Loa loa; Ls, Litomosoides sigmodontis; Mh, Meloidogyne hapla; Na, Necator americanus; Nb, Nippostrongylus brasiliensis; Od, Oesophagostomum dentatum; Ov, Onchocerca volvulus; Pp, Pristionchus pacificus; Sr, Strongyloides ratti; Ta, Trichostrongylus axei; Tc, Trichostrongylus colubriformis; Tsp, Trichinella spiralis; Tsu, Trichuris suis; Wb, Wuchereria bancrofti.