Table III.

Severity of white matter abnormalities as predictors of motor impairment at 5y

Motor impairment	White matter abnormalitya	Unadjusted odds ratiob (95% CI)	p value	Adjusted odds ratioc (95% CI)	p value
All participants (n=193)
Moderate–severe impairment	Mild	5.6 (1.9–16.3)	0.002	6.6 (2.0–21.9)	0.002
	Moderate–severe	19.4 (5.6–66.7)	<0.001	38.4 (8.8–167.0)	<0.001
Mild–severe impairment	Mild	2.2 (1.1–4.2)	0.02	2.0 (1.0–4.1)	0.06
	Moderate–severe	9.4 (3.2–28.1)	<0.001	10.2 (3.2–32.7)	<0.001
Excluding infants with cerebral palsy at 2y (n=178)
Moderate–severe impairment	Mild	4.5 (1.5–12.8)	0.006	4.9 (1.5–16.5)	0.01
	Moderate–severe	10.7 (3.0–38.5)	<0.001	20.1 (4.4–92.6)	<0.001
Mild–severe impairment	Mild	2.0 (1.0–3.9)	0.04	1.8 (0.9–3.6)	0.12
	Moderate–severe	6.2 (2.0–18.6)	0.001	6.3 (1.9–20.8)	0.002

^aGrade of white matter abnormality compared with no white matter abnormality;

^bResults adjusted for clustering of multiples only;

^cResults adjusted for sex, gestational age at birth, birthweight z-score, high social risk, and bronchopulmonary dysplasia (n=190 and 175 in the analysis including and excluding children with cerebral palsy at 2y respectively); Moderate–severe impairment is defined as Movement Assessment Battery for Children total impairment score ≤5th centile; mild–severe impairment is defined as Movement Assessment Battery for Children total impairment score ≤15th centile.

CI, confidence interval.