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. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(48):9097–9101. doi: 10.1002/anie.200904504

Figure 1.

Figure 1

Photocontrol of K+ channels. a) Structures and photoisomerization of photoswitchable K+ channel blockers. b) Cartoon depicting a PCL for the internal TEA-binding site. The linear trans isomer is a better blocker than the bent cis isomer. c) Cartoon depicting a PTL for the external TEA-binding site. The extended trans isomer presents the blocking particle to the pore while the shorter cis isomer is unable to reach. PCL: photochromic ligand, PTL: photoswitchable tethered ligand, TEA: tetraethylammonium.