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A schematic of glycopeptide enrichment from dilute solutions using mesoporous silica material modified with boronic acid. The pores act as a nanoreactor for the specific binding of di-boronic acid groups to glycopeptides (top half of the figure). FE-SEM images of boronic acid-modified mesoporous silica material at low magnification (a) and the high-resolution image of the squared area in part a; and (b) TEM images along the vertical direction of the mesoporous materials (c,d)[41].
