Table 2.
Second and third-generation vaccine trials with potent vaccine targets
| Vaccine targets | Subcellular location |
Type of vaccine | Experimental model |
References |
|---|---|---|---|---|
| HSP/HSC/LmSTI-1 | Cytosol | DNA Native antigen+MPL/ALD | Mice | [164, 165] |
| gp63 | Memberane | DNA vaccine(DNA+pCMV) | Mice | [166, 167] |
| H1 | Nucleus | Recombinant protein | Mice | [168] |
| CPa+CPb | Cytosol | Recombinant protein | Dog | [169] |
| LACK | Cytosol | Recombinant protein | Mice | [170] |
| P0 | Ribosome | Recombinant protein | Mice | [106] |
| LACK | Cytosol | DNA vaccine | Mice | [171] |
| KMP-11 | Memberane | pcDNA-LIC | Hamester | [122] |
| A2 | Cytosol | Recombinant protein | Mice | [172] |
| LACK | Cytosol | pcDNA-3+vaccinia virus | Mice | [36] |
| CPa or CPb,CPa+CPb | Cytosol | pCB6 | Mice | [173] |
| H2A-H2B and H3,H4 | Nucleus | DNA vaccine | Mice | [174] |
| LACK | Cell surface | DNA vaccine | Mice | [175] |
| HASPB | Cell surface | Recombinant protein | Mice | [176] |
| LPG | Cell surface | native antigen+BCG | Mice | [177] |
| Hb-receptor | Flagellar pocket | DNAvaccine | Mice and hamster | [43] |
| LiP0- PB | Cytosol | pcDNA3 | MiceMice | [178] |
| CPc-PB | Cytosol | DNA vaccine | Hamster Mice and human | [92] |
| KMP-11 | Cell surface | DNA vaccine | [122] | |
| Leish111-f | - | Recombinant poly protein | [39] | |
| LiESA/QA-21 | Excreted/secreted protein | Recombinant protein | Dog | [179] |
- PB- Prime- boost