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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Expert Rev Vaccines. 2014 Apr;13(4):489–505. doi: 10.1586/14760584.2014.894467

Table 2.

Second and third-generation vaccine trials with potent vaccine targets

Vaccine targets Subcellular
location
Type of vaccine Experimental
model
References
HSP/HSC/LmSTI-1 Cytosol DNA Native antigen+MPL/ALD Mice [164, 165]
gp63 Memberane DNA vaccine(DNA+pCMV) Mice [166, 167]
H1 Nucleus Recombinant protein Mice [168]
CPa+CPb Cytosol Recombinant protein Dog [169]
LACK Cytosol Recombinant protein Mice [170]
P0 Ribosome Recombinant protein Mice [106]
LACK Cytosol DNA vaccine Mice [171]
KMP-11 Memberane pcDNA-LIC Hamester [122]
A2 Cytosol Recombinant protein Mice [172]
LACK Cytosol pcDNA-3+vaccinia virus Mice [36]
CPa or CPb,CPa+CPb Cytosol pCB6 Mice [173]
H2A-H2B and H3,H4 Nucleus DNA vaccine Mice [174]
LACK Cell surface DNA vaccine Mice [175]
HASPB Cell surface Recombinant protein Mice [176]
LPG Cell surface native antigen+BCG Mice [177]
Hb-receptor Flagellar pocket DNAvaccine Mice and hamster [43]
LiP0- PB Cytosol pcDNA3 MiceMice [178]
CPc-PB Cytosol DNA vaccine Hamster Mice and human [92]
KMP-11 Cell surface DNA vaccine [122]
Leish111-f - Recombinant poly protein [39]

LiESA/QA-21 Excreted/secreted protein Recombinant protein Dog [179]

- PB- Prime- boost