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. 2004 Apr 14;101(17):6403–6408. doi: 10.1073/pnas.0307697101

Fig. 2.

Fig. 2.

RNAi for newly identified modifiers of polyglutamine aggregate formation induces aggregates and insolubilization of polyglutamine proteins that depend on the length of the Q stretch. (A–C) Fluorescence microscopy pictures of 4-day-old C. elegans expressing Q35 YFP fed with control RNAi food (A) and two examples of positive clones expressing dsRNA against hsp-6 (B) and snr-4 (C). (Bar = 50 μm.) (D) Western blot analysis of extracts of animals expressing Q24 YFP or Q35 YFP, fed with bacteria expressing dsRNA for the indicated genes. Genes are grouped according to their functional classes.