Fig. 3.

Overview of modifiers of polyglutamine aggregation. Represented are the five major classes of genes of which knock-down by RNAi enhances polyglutamine aggregate formation. We propose that knock-down of genes in these classes induces aggregate formation either by an increase in the production of misfolded proteins (green line) or by a decrease in the clearance of misfolded proteins (red line). Between brackets is the number of genes found in the indicated functional class.