Table 1. Overview of modifiers of polyglutamine aggregation (see Table 3 for full list of genes).

Cellular process (no. of genes)*	Function (no. of genes)*†	Cosmid no.	Gene example	Gene description	Mammalian homologue
RNA synthesis and processing (38)	Synthesis (14)	F36A4.7	ama-1	Largest subunit of RNA polymerase II	RPB1
	Splicing (19)	T13H5.4	phi-9	Putative U2 snRNP-associate splicing factor	SAP61/SF3a60
Protein synthesis (53)	Initiation (5)	Y39G10AR.8	eif-2	Translation initiation factor elF2	elF-2-γ
	Elongation (4)	F25H5.4	eft-2	Elongation factor 2	eEF1A-2
	Ribosomal subunit (40)	F39B2.6	rps-26	Ribosomal protein S26	40S ribosomal protein S26
Protein folding (10)	Chaperonin (6)	C07G2.3	cct-5	Homologue chaperonin TCP-1, subunit 5 (ε)	TCP-1-ε
	Hsp70 (2)	C37H5.8	hsp-6	Member of the heat-shock HSP70 protein family	GRP75
	DnaJ (1)	F18C12.2	rme-8	Heat-shock protein DnaJ, N-terminal	Unknown
Protein transport (25)	Vesicle (14)	C39F7.4	rab-1	GTP-binding protein of the rab family	RAB-1A
	Nuclear import (5)	C53D5.6	imb-3	Putative karyopherin β	Importin β-3 subunit
	Cytoskeleton (6)	C36E8.5	tbb-2	Member of the β-tubulin protein family	Tubulin β-2 chain
Protein degradation (14)	19S (4)	F56H1.4	rpt-5	Putative ATPase subunit of the 19S regulatory complex	26S protease regulatory subunit 6A
	20S (7)	C36B1.4	pas-4	Putative α4 20S proteasome core subunit	Proteasome subunit α type 7
	Ubiquitin like (1)	F52C6.3	phi-37	Member of the ubiquitin family	Ubiquitin C
	E1 Ub-activating enzyme (1)	C47E12.5	uba-1	Similarity to ubiquitin-activating enzyme E1	Ubiquitin activating enzyme E1
Other (46)	ATP synthesis (6)	H28O16.1	phi-44	Putative ATP synthase	ATP synthase α chain mitochondrial precursor

^*Number of genes found in the indicated categories

^†Major functional groups from each category of cellular process