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. 2014 May 8;111(21):7723–7728. doi: 10.1073/pnas.1318761111

Fig. 3.

Fig. 3.

Tgfbm3b is a TGFβ1-dependent modifier of adult CEPC response to angiogenesis. Three mouse strains: (i) NIH, (ii) congenic NIH.Tgfbm3a line 4, and (iii) NIH.Tgfbm3ab line 6, were implanted with syngeneic CarB cells (2 × 105) expressing high VEGF and SDF1 levels, to provide an angiogenic stimulus. Blood was harvested at the indicated time points post-CarB implantation, and assayed by FACS analysis for (A) CD45−, CD13+, CD117− CECs, and (B) (CD45−, CD13+, and CD117+) CEPCs. Similar experiments were performed using NIH.Tgfbm3ab line 6 congenic mice that were either wild type or haploinsufficient for Tgfb1 (C and D). Each time point represents data from four mice per genotype, and each experiment was independently reproduced three times.