Table 1. SI50 values for the cytotoxicity of PA+LFnCdtB or PA+FP59AGG NCI-60 panel cell lines and murine cell lines.
| Cell line |
SI50
(nM) |
|
|---|---|---|
| LFnCdtB | FP59AGG | |
| Melanoma | ||
| C32 | 0.00035 | 0.0022 |
| Malme-3M | >>10 | 0.0027 |
| SK-MEL-2 | >>10 | 0.010 |
| SK-MEL-24 | 0.77 | 0.017 |
| SK-MEL-28 | >10 | 0.0021 |
| Colon | ||
| COLO 205 | 0.11 | 0.008 |
| HCC2998 | 0.085 | 0.0037 |
| SW620 | 0.31 | 0.024 |
| Lung | ||
| A549 | 1.6 | 0.002 |
| NCI-H226 | >10 | 0.00043 |
| Breast | ||
| MDA-MB-231 | 0.018 | 0.0068 |
| Hs 578T | 0.18 | 0.037 |
| Kidney | ||
| A-498 | 0.072 | 0.008 |
| SN12C | 0.083 | 0.00038 |
| HN6 (head and neck) | 0.14 | ND |
| HeLa (cervical) | 0.0037 | ND |
| Murine/Chinese hamster | ||
| CHO K1 (Chinese hamster) | 0.00048 | ND |
| RAW264.7 | 0.0037 | ND |
| T241 | 0.27 | 0.064 |
| LL3 (PA) | 0.76 | 0.026 |
| LL3 (PA-L1) | 0.33 | 0.073 |
| B16/BL6 (PA) | 0.021 | 0.0005 |
| B16/BL6 (PA-L1) | 0.038 | 0.054 |
Abbreviations: NA, not determined; PA, protective antigen; SI50, 50% survival index