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. 2014 Jan 23;5(1):e1014. doi: 10.1038/cddis.2013.554

Figure 5.

Figure 5

PGP9.5-staining shows epidermal-terminal innervation (arrows) in the hind plantar paw skin of normal mice (a) similar to those in [Pt(O,O'-acac)(γ-acac)(DMS)]-treated mice (c). Loss of PGP9.5 positive nerve fibers is evident following cisplatin treatment (b). Scale bar 100 μm. (d) Hindpaw sensitivity to cold and noxious heat was significantly increased in cisplatin- but not in [Pt(O,O'-acac)(γ-acac)(DMS)]-treated mice compared with vehicle-treated mice, as determined by reduced hindpaw withdrawal latency to immersion in cold water (4.5 °C). Bars represent the mean±S.E.M. of mice per group. *P<0.05 versus vehicle group. #P<0.05 versus [Pt(O,O'-acac)(γ-acac)(DMS)] group