Table 1. Pharmacokinetic parameters for [Pt(O,O'-acac)(γ-acac)(DMS)].
Pharmacokinetic parameters | AUC0–24 (h-μg/ml) | Cmax (μg/ml) | Tmax (h) | CL (ml/h) | Vd (ml/kg) | Λ |
---|---|---|---|---|---|---|
In plasma | 868.20 | 90.21 | 0.5 | 0.57 | 1.8 | 0.32 |
In whole blood | 263.33 | 68.78 | 0.5 | 2.6 | 8.4 | 0.31 |
Abbreviations: AUC, area under curve; Cmax, maximum concentration observed; CL, clearance; Tmax, time at maximum concentration; Vd, volume of distribution