Figure 5.

iNOS deficiency abrogated the therapeutic effects of MSCs. (a) The serum concentrations of TB, Alb, ALT, and AST in mice from each group were determined. (b) Fibrin deposition was detected by sirius red staining ( × 40 magnification, scale bar=200 μm). The liver showed extensive fibrotic development, formation of regenerative nodules, and distortion of the vascular architecture in mouse cirrhotic liver without MSCs transfusion. (c and d) Quantitative analysis of the presence of liver fibrosis and fat vacuoles. For this figure, values are shown as mean±S.E.M. and statistical significance indicated as ***P<0.001. Representative of three independent experiments; n=7–10