Figure 5.

Effect of aflatoxin B1, leptomycin B and ivermectin, on nucleo-cytoplasmic shuttling of GFP fused PfSRP9. Synchronised ring stage infected erythrocytes at 2% initial parasitemia were treated with these inhibitors and imaged at different time intervals. (a) upper panel, DMSO treated control parasite after 24 h of treatment, lower panel, AflatoxinB1 (AFB1, 10 μM ) treated parasite at 24 h after treatment. (b) LeptomycinB (LMB, 25 ng/ml ) treated parasite at 24 h after treatment and (c) parasite after 24 h of ivermectin (IVM) treatment at10 μM and 25 μM, respectively