Figure 6.

Effect of Ivermectin on localisation of GFP fused PfSRP14 and growth of parasite. (a) i and ii show three dimensional reconstruction of confocal Z-stack merged images of GFP fused control trophozoite with DAPI (blue) as nuclear marker merged with DIC. (b) and (c), show the three dimensional reconstruction of confocal Z-stack merged images of GFP fused PfSRP14 with DAPI as nuclear marker merged with DIC in control and Ivermectin (10 μM) treated parasite at 24 h after treatment. (d) dose dependent effect of ivermectin on growth of P. falciparum 3D7, MCamp and Dd2 by SYBR Green assay (e) In-vivo effect of ivermectin against P. berghei in mice