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. 2014 Jan 23;5(1):e1019. doi: 10.1038/cddis.2013.559

Figure 1.

Figure 1

Synaptopathy occurred in TgCRND8 mice, already at an early stage of AD pathology. (a–h) Western blot and relative quantification performed on the TIF fraction of 2-months-old Wt and TgCRND8 mice. Tg mice showed a significant reduction in the PSD levels of GluN2A (31%) (b) and of GluN2B (54%) (c) subunits of NMDAr, as well as reduction of GluA1 (46%) (d) and of GluA2 (35%) (e) subunits of AMPAr, of PSD-95 (35%) (f) and of drebrin (60%) (g) if compared with age-matched Wt mice (Student's t-test, *P<0.05, **P<0.01, ***P<0.001, n=6). Tubulin levels were not affected (h) (Student's t-test, P>0.05, n=6). (i–p) Western blot and relative quantification performed on the TIF fraction of 9-months-old Wt and TgCRND8 mice. Tg mice showed a severe reduction in the PSD levels of GluN2A (74%) (j) and of GluN2B (86%) (k) subunits of NMDAr, as well as reduction of GluA1 (66%) (l) and of GluA2 (71%) (m) subunits of AMPAr, of PSD-95 (80%) (n) and of drebrin (84%) (o) if compared with age-matched Wt mice (Student's t-test, *P<0.05, **P<0.01, ***P<0.001, n=6). Tubulin levels were not affected (p) (Student's t-test, P>0.05, n=6)