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. 2014 Jan 16;5(1):e996. doi: 10.1038/cddis.2013.499

Figure 2.

Figure 2

Role of HCV viral proteins in the induction of apoptosis. The positive-stranded genome RNA of HCV encodes structural proteins (core, E1, E2, and p7) and non-structural proteins (NS2, NS3, NS4A, NS4B, NS5A, and NS5B). Special structures of HCV genome determine not only particular entry pattern of infectious HCV, but death mode of infected hepatocytes and immune escape mechanism as well