Table 2. Clinical features of HPV-positive and -negative HNSCC.

	HPV negative	HPV positive	References
Aetiology	Tobacco/alcohol	HPV infection	2,5,78
Age	Above 60 years	Below 60 years	5
p53 mutations	Highly frequent	Infrequent	20,27
Site	Not predictable	Oropharynx	78
Prognosis	Poor	Favourable	77,87