Figure 2.

Time course of serum glutamate concentration (μM) in MCAO rats. MCAO rats were treated with saline (control group) (n=6), oxaloacetate (Oxal) 3.5 mg per 100 g (n=6), rGOT1 12.88 μg per 100 g (n=6) and rGOT1 12.88 μg per 100 g plus oxaloacetate 1.5 mg per 100 g (n=6). Solid arrow indicates the time of treatment injection, administered at the moment of reperfusion (80 min after occlusion). Serum glutamate concentration was measured under basal conditions (before surgery), at the moment of the reperfusion (before treatment administration), and 1, 2 and 3 h after reperfusion. Data are shown as mean±S.E.M. *P<0.05, **P<0.01 compared with control group