Figure 5.

Infarct size assessed by means of MRI in MCAO rats. MCAO rats were treated with saline (control group), oxaloacetate (Oxal) 3.5 mg per 100 g, rGOT1 12.88 μg per 100 g and rGOT1 12.88 μg per 100 g plus oxaloacetate 1.5 mg per 100 g. Treatments were administered at the moment of the reperfusion. Infarct size was assessed in ischemic rats not subjected to spectrocopy analysis (a) as well as in ischemic rats subjected to spectroscopy analysis (b). Infarct sizes were measured at 24 h and 7 days after ischemia. Only those animals subjected to spectroscopy analysis presented ADC basal volumes (determined before the administration of treatment). Data are shown as the mean of infarct volume (mm³)±S.E.M in a, and percentage relative to the basal volume in b. *P<0.05, **P<0.01 with respect to the control group at 24 h; ^#P<0.05, ^##P<0.01 as well as on day 7