Figure 6.

Time course of serum glutamate concentration (μM) in MCAO rats. MCAO rats were treated with saline (control group) (n=6), rGOT1 12.88 μg per 100 g (n=6) and rGOT1 12.88 μg per 100 g plus oxaloacetate 1.5 mg per 100 g (n=6) 1 h after reperfusion. Solid arrow indicates the time of the i.v. treatments. Serum glutamate concentration was measured under basal conditions (before surgery), at the time of reperfusion (before treatment administration), and 1, 2 and 3 h after reperfusion. Data are shown as mean±S.E.M. *P<0.05, **P<0.01 with respect to the control group