Figure 2.

Management of HIV-HCV co-infected genotype-1 patients according to fibrosis stage and prior treatment outcome (adapted from EACS Guidelines, version November 2012) [Ingiliz and Rockstroh, 2012].

^aMetavir fibrosis score: F0 = no fibrosis; F1 = portal fibrosis, no septae; F2 = portal fibrosis, few septae, F3 = bridging fibrosis, F4 = cirrhosis.

^bMonitor fibrosis stage annually, preferably with two established methods. Treat with triple therapy, if rapid progression.

^cAs the overall cure rates in patients with cirrhosis and previous nonresponse is estimated to be very low (<15%) triple therapy needs to be discussed on an individual basis balancing low probability of cure rate, increased risk for adverse events and further disease progression.