Figure 4.

(A) Weekly change from baseline in worst abdominal pain rating in study 302. Worst abdominal pain was assessed daily on a 0–10 scale and percentage change was calculated as weekly change multiplied by 100, divided by baseline score. p < 0.0001 (linaclotide versus placebo, generalized linear model analysis of covariance), modified from Chey et al.²⁴ (B) Weekly change from baseline in bloating severity in study 302 (intent-to-treat population, observed cases). Bloating was assessed daily on a 0–10 scale and percentage change was calculated as weekly change multiplied by 100, divided by baseline score. p < 0.0001 (linaclotide versus placebo, generalised linear model analysis of covariance), modified from Quigley et al.²⁵