Figure 1.

Gelatine tannate ameliorates DSS colitis in mice.

Mice receiving 2.5% DSS in drinking water ad libitum were treated with 1 or 10 mg gelatin tannate or saline, given orally by gavage starting on day 3. Mice were monitored for bodyweight changes compared to baseline (a) and disease activity index (b). At sacrifice, colon length was measured (c) and histology assessment by a well-established score was performed (d). At microscopy (e), samples from gelatin tannate-treated mice showed an amorphous layer overlaying the inflamed mucosa probably due to the action of gelatin tannate.