Table 2.
Predictors of WAZ score change after 6 months of ARTa
| Predictor | Number | Univariate | P | Number | Multivariateb | P |
|---|---|---|---|---|---|---|
| Disease stage | 1694/3144 | <0.001 | 1694/3144 | <0.001 | ||
| I | Reference | Reference | ||||
| II | 0.07 (–0.09, 0.23) | 0.13 (–0.04, 0.30) | ||||
| III | 0.30 (0.17, 0.42) | 0.22 (0.08, 0.37) | ||||
| IV | 0.69 (0.39, 1.00) | 0.45 (0.16, 0.74) | ||||
| ARV regimen | 1694/3144 | 0.02 | 1694/3144 | 0.05 | ||
| No stavudine | Reference | Reference | ||||
| Contains stavudine | 0.15 (0.02, 0.28) | 0.12 (0.001, 0.24) | ||||
| ARV regimen | 1694/3144 | 0.78 | 1694/3144 | 0.89 | ||
| No efavirenz | Reference | Reference | ||||
| Contains efavirenz | –0.02 (–0.19, 0.14) | 0.01 (–0.15, 0.17) | ||||
| Anemia, g/dlc | 1694/3144 | 0.001 | 1694/3144 | 0.02 | ||
| No | Reference | Reference | ||||
| Yes | 0.27 (0.11, 0.44) | 0.17 (0.02, 0.31) | ||||
| Age, years | 1694/3144 | 0.001 | 1694/3144 | <0.001 | ||
| 0–2 | Reference | Reference | ||||
| >2–5 | –0.01 (–0.15, 0.14) | –0.07 (–0.21, 0.06) | ||||
| >5 | –0.22 (–0.36, –0.09) | –0.30 (–0.43, –0.17) | ||||
| Use of cotrimoxazole | 1694/3144 | 0.77 | 1694/3144 | 0.37 | ||
| No | Reference | Reference | ||||
| Yes | 0.02 (–0.09, 0.12) | –0.05 (–0.15, 0.06) | ||||
| Opportunistic infectionsd | 1694/3144 | 0.07 | 1694/3144 | 0.41 | ||
| No | Reference | Reference | ||||
| Yes | 0.16 (–0.01, 0.33) | 0.07 (–0.09, 0.23) | ||||
| Pulmonary TB | 1694/3144 | 0.21 | 1694/3144 | 0.70 | ||
| No | Reference | Reference | ||||
| Yes | 0.08 (–0.04, 0.20) | 0.02 (–0.10, 0.15) | ||||
| Severe immune suppression (CD4+ T-cells < 15% if ≤5 years; <200 cells/μl if >5 years)e | 1694/3144 | <0.001 | 1694/3144 | <0.001 | ||
| No | Reference | Reference | ||||
| Yes | 0.37 (0.25, 0.50) | 0.29 (0.18, 0.41) | ||||
| Underweight at ART initiation (WAZ < –2 SD) | 1694/3144 | <0.001 | 1694/3144 | <0.001 | ||
| No | Reference | Reference | ||||
| Yes | 0.82 (0.73, 0.92) | 0.78 (0.67, 0.88) |
aLinear regression models.
bAdjusted for factors indicated in the table plus gender, district of residence and calendar year.
cHemoglobin: <11 g/dl (age < 5 years); <11.5 g/dl (age 5–11 years); <12 g/dl (age 12–14 years).
dPatient having at least one or more of the following: herpes zoster, fungal infection, oral candidiasis, oral hairy leukoplakia, recurrent severe bacterial infection, pneumocystis jirovecii pneumonia, toxoplasmosis, cryptosporidiosis with diarrhea, cryptococcal meningitis, extrapulmonary TB, lymphoma, kaposis sarcoma, HIV encephalopathy.
eAdopted from CDC. Guidelines for Preventing Opportunistic Infections Among HIV-Infected Persons – 2002. MMWR 14 June 2002 (CDC).