Table 2. Summary of functional classification of sequences related to 13 human tumor suppressor proteins.
| Protein (residues, subalignment identification, number of sequences in subalignment) | Examples of nonmammalian sequences (protein accession identification, residues, sequence identity to query) |
|---|---|
| APC (1—2843, 32%, 15) | Xenopus laevis (AAB41671, 1—2,829, 71%) |
| ARF (1—179, 44%, 11) | All mammals |
| BRCA1 (1—1863, 32%, 99) | X. laevis (AAL13037, 1—234, 41%), fragment |
| BRCA2 (1—3418, 37%, 24) | Arabidopsis thaliana (NP_191913, 106—204, 37%), fragment |
| INK4A (1—156, 33%, 19) | Xiphophorus helleri (AAD21313, 7—121, 57%) |
| NF1 (1—2839, 29%, 58) | Takifugu rubripes (AAD15839, 1—2,763, 88%) |
| Anopheles gambiae (EAA08440, 3—2,787, 60%) | |
| NF2 (1—595, 48%, 19) | A. gambiae (EAA07087, 56—635, 57%) |
| Drosophila melanogaster (AAM11326, 7—468, 54%) | |
| P53 (1—393, 53%, 118) | A. gambiae (P10361, 1—391, 79%) |
| X. laevis (P07193, 2—363, 56%) | |
| PTC (1—1447, 27%, 44) | X. laevis (AAK15463, 1—1,417, 80%) |
| D. melanogaster (A33468, 23—1,198, 41%) | |
| PTEN (1—403, 38%, 22) | X. laevis (AAD46165, 1—402, 89%) |
| T. rubripes (AAL08419, 1—412, 88%) | |
| RB (1—928, 61%, 25) | Gallus gallus (CAA51019, 1—921, 74%) |
| Notophthalmus viridescens (CAA70428, 2—899, 62%) | |
| X. laevis (A44879, 1—899, 61%) | |
| VHL (1—213, 33%, 9) | A. gambiae (EAA07955, 26—168, 33%) |
| WT1 (1—449, 31%, 110) | X. laevis (P18753, 591—760, 35%), fragment |
The only nonmammalian sequences included in the subalignments selected to represent BRCA1, BRCA2, and WT1 are short sequence fragments. The complete list of sequences is available upon request.