Figure 2.

Somatic mutations are associated with disease risk and MDS subtype. (A) Kaplan-Meier curve from Papaemmanuil et al.³⁹ showing leukemia-free survival in 595 MDS patients stratified by the number of tumor mutations identified. (B) Similar figure from Bejar et al.³⁸ demonstrating the relationship between overall survival and mutation number in 439 MDS patients. (C) Data from Haferlach et al.⁴⁰ showing differences in mutation number across MDS subtypes. Reprinted with permission.