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. 2014 Jun;99(6):1016–1021. doi: 10.3324/haematol.2013.103143

Figure 2.

Figure 2.

Effect of Tmprss6 deletion on the Bmp-Smad pathway of Tfr2−/− and Tfr2LCKO mice. The graphs show liver mRNA expression of: bone morphogenetic protein 6 (Bmp6; A); hepcidin (Hamp; B); Hamp normalized on LIC (Hamp/LIC; C) and inhibitor of DNA binding 1 (Id1; D) in all genotype combinations analyzed. Mean values of three to six animals per genotype are shown and error bars indicate the standard deviation. Symbols refer to a statistically significant difference: *P<0.05, **P<0.01 and ***P<0.005 respective to the relative Tmprss6+/+ control of each Tfr2 genotype; #P<0.05 respective to wild-type (Tmprss6+/+Tfr2+/+) animals; §P<0.05 respective to Tmprss6−/− mice. For the complete statistical analysis see Online Supplementary Table S2.