Table 3.
Genetic variance explained by the total number of independent loci discovered in the eligible GWA meta-analyses
| Disease/Trait | SNPs Discovered | % Genetic Variance Explained |
|---|---|---|
| Stroke (S29) | 2 | 4.97 |
| Atrial fibrillation (S4) | 2 | 4.23 |
| Major mood disorders (S44) | 1 | 0.94 |
| Alanine aminotransferase (ALT) (S33) | 2 | 0.60 |
| Aspartate aminotransferase (AST) (S33) | 2 | 0.84 |
| Blood urea nitrogen (S33) | 3 | 0.89 |
| Gamma glutamyl transpeptidase (y-GT) (S33) | 2 | 1.96 |
| Hemoglobin (S33) | 2 | 0.61 |
| Hematocrit (S33) | 2 | 0.56 |
| Mean corpuscular hemoglobin (S33) | 15 | 6.98 |
| Mean corpuscular hemoglobin concentration (S33) | 7 | 2.07 |
| Mean corpuscular volume (S33) | 15 | 6.56 |
| Platelets count (S33) | 6 | 2.19 |
| Red blood cells count (S33) | 8 | 3.47 |
| Total protein (S33) | 2 | 0.69 |
| White blood cells count (S33) | 5 | 1.28 |
| Serum creatinine (S33) | 1 | 0.22 |
| Height a (S51) | 8 | 1.78 |
| Intracranial aneurysm (S87) | 6 | 12.20 |
| Birth weight (S23) | 2 | 0.51 |
| Heart failure (S68) | 1 | 1.12 |
| Rheumatoid arthritis b (S74) | 6 | 51.65 |
| Vitamin D insufficiency (S84) | 3 | 12.86 |
| Phosphorus levels (S36) | 7 | 0.39 |
| Type 2 diabetes b (S81) | 10 | 13.09 |
| Calcium levels (S50) | 1 | 0.09 |
| Asthma (S47) | 6 | 5.71 |
| Height b (S41) | 115 | 6.56 |
| Gout (S86) | 2 | 14.34 |
| Waist-hip ratio (S27) | 12 | 0.60 |
| Crohn’s disease (S22) | 52 | 71.21 |
| Renal cell carcinoma (S58) | 6 | 5.38 |
| Parkinson’s disease (S32) | 11 | 20.17 |
| Ulcerative colitis (S2) | 33 | 39.17 |
| Coronary heart disease (S66) | 13 | 9.01 |
| Alzheimer’s disease (S28) | 6 | 5.78 |
| Glioma (S62) | 6 | 12.19 |
| Adiposity (% body fat) (S38) | 2 | 0.27 |
| Sudden cardiac arrest (S3) | 2 | 6.757 |
| Ankylosing spondylitis (S21) | 7 | 78.63 |
| Proinsulin levels (S76) | 7 | 0.67 |
| Type 2 diabetes a (S39) | 1 | 2.09 |
| Coffee consumption (S1) | 1 | 0.005 |
| Plaque (S5) | 3 | 2.48 |
| Bipolar disorder (S64) | 4 | 3.70 |
| Pulmonary function (S70) | 8 | 0.69 |
| Type 1 diabetes (S8) | 19 | 36.42 |
| Height c (S49) | 2 | 0.30 |
| Allergic rhinitis (S60) | 1 | 1.22 |
| IgE sensitization to grass (S60) | 3 | 5.54 |
| Aortic stiffness (carotid-femoral pulse wave velocity) (S46) | 1 | 0.26 |
| Multiple sclerosis (S54) | 9 | 49.08 |
| Atopic dermatitis (S53) | 2 | 1.76 |
| Ankle-brachial index (S48) | 1 | 0.002 |
| Metabolic syndrome (S40) | 1 | 2.07 |
| Rheumatoid arthritis a (S52) | 7 | 32.90 |
| Chronic kidney disease (S55) | 2 | 2.74 |
| Adiponectin levels (S12) | 10 | 0.72 |
| Obesity (childhood) (S9) | 7 | 10.15 |
| Head circumference (infant) (S77) | 3 | 0.77 |
| Bone mineral density- Femoral neck (S19) | 22 | 3.89 |
| Bone mineral density- Lumbar spine (S19) | 26 | 5.62 |
GWA, genome-wide association; SNP, single-nucleotide polymorphism
a
It pertains to populations of Asian ancestry
b
It pertains to populations of European ancestry
c
It pertains to populations of African ancestry