TABLE 2 Proposed Drug Addiction Reward Gene Panel
| Gene | Significant | Comment |
|---|---|---|
| ALDH2** | P = 5 × 10–37 | With alcoholism and alcohol-induced medical diseases. |
| ADH1B** | P = 2 × 10–21 | With alcoholism and alcohol-induced medical diseases. |
| ADH1C** | P = 4 × 10–33 | With alcoholism and alcohol-induce medical diseases. |
| DRD2* | P = 1 × 10–8 | With alcohol and drug abuse. |
| DRD4* | P = 1 × 10–2 | With alcohol and drug abuse. |
| SLC6A4** | P = 2 × 10–3 | With alcohol, heroin, cocaine, methamphetamine dependence |
| HTRIB* | P = 5 × 10–1 | With alcohol and drug abuse. |
| HTRI2A* | P = 5 × 10–1 | With alcohol and drug abuse. |
| TPH* | P = 2 × 10–3 | With alcohol and drug abuse. |
| MAOA* | P = 9 × 10–5 | With alcohol and drug abuse. |
| OPRD1** | P = 5 × 10–1 | With alcohol and drug abuse. |
| GABRG2** | P = 5 × 10–4 | With alcohol and drug abuse. |
| GABRA2* | P = 7 × 10–4 | With alcohol and drug abuse. |
| GABRA6** | P = 6 × 10–4 | With alcohol and drug abuse. |
| COMT* | P = 5 × 10–1 | With alcohol and drug abuse in Asians. |
| DAT1* | P = 5 × 10–1 | With alcohol and drug abuse in Asians. |
| CNR1* | P = 5 × 10–1 | With alcohol and drug abuse. |
| CYP2E1** | P = 7 × 10–2 | With alcohol liver disease. |
| ANKKI** | P = 5 × 10–6 | With alcohol and drug abuse. |
*
US and European patents issued
**
US & PTC pending
Reproduced from Chen et al. 2011. Independent analysis by Li, Zhao, and Galanter presented at XVII World Congress of Psychiatric Genetics Abstract (#ECI16) Nov 4–8, San Diego, CA 2009.