Table 2.
Rare Variants in 16 Candidate Genes Linked to hVISA/VISAa
| Candidate Genes | Etest |
PAP-AUC |
||
|---|---|---|---|---|
| VSSA (n = 49) | VISA (n = 26) | VSSA (n = 26) | hVISA/VISA (n = 49) | |
| walR | 1 | 5 | 0 | 6 |
| walK | 6 | 5 | 2 | 9 |
| rpoB | 8 | 8 | 7 | 9 |
| sarA | 1 | 0 | 1 | 0 |
| graR | 0 | 1 | 0 | 1 |
| graS | 1 | 1 | 1 | 1 |
| vraF | 2 | 1 | 2 | 1 |
| vraG | 4 | 4 | 3 | 5 |
| clpP | 0 | 0 | 0 | 0 |
| stp1 (PP2C) | 4 | 4 | 4 | 4 |
| ccpA | 1 | 0 | 0 | 1 |
| prsA | 3 | 0 | 1 | 2 |
| vraR | 1 | 2 | 1 | 2 |
| vraS | 1 | 2 | 1 | 2 |
| yvqF | 5 | 7 | 4 | 8 |
| agrA | 0 | 1 | 0 | 1 |
aThe number of rare variants causing nonsynonymous changes (present in <100 out of 3,277 S. aureus genomes) for each candidate gene are listed, categorized by whether they are found exclusively in VISA strains (for the Etest-based classification) or hVISA/VISA (PAP-AUC) for the 75 strains sequenced in this study.