Table 3.

Molinspiration calculation of 4-aminoantipyrine derivatives 4(a–h).

Compounds	MW	mi log P	TPSA	OH-HN	N violation	Volume
4a	481	3.98	117	2	0	421
4b	481	3.96	117	2	0	421
4c	466	4.10	81	2	0	423
4d	479	4.12	75	2	0	444
4e	452	3.57	92	3	0	406
4f	452	3.99	92	3	0	406
4g	470	4.72	72	2	0	411
4h	470	4.68	72	2	0	411
Diclofenac	296	4.56	49	2	0	238
Albendazole	265	2.74	67	2	0	234

MW: molecular weight; TPSA: Topological polar surface area.