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. 2014 May 19;9:18. doi: 10.1186/1750-1326-9-18

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Copyright © 2014 Overk et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Decreased number of hippocampal CA3 but not CA1 pyramidal cells in APP, α-syn, and α-syn/APP tg mice. A. Representative low- and high-photomicrographs of the hippocampal CA3 and CA1 regions of sections immunoreacted with NeuN. B. Stereological assessment of every 12^th section revealed a significant decrease in the number of neurons in the CA3. C. However, the number of neurons in the CA1 region was unaffected across all tg mouse line. Statistical analysis was conducted using one-way ANOVA post hoc Dunnett’s compared to non-tg mice; * p-value < 0.05. For analysis N = 3 (3–4 mos old) from each line were utilized.