Table 2.
Risk of colorectal cancer, overall and according to clinicopathological factors, in relation to HRT and ERT use
| Tumour subgroups | HRT use | Number of cases | HR crude | p | HR adjusted | p |
|---|---|---|---|---|---|---|
| CRC |
No |
236 |
1.00 |
|
1.00 |
|
| ERT |
24 |
0.89(0.59-1.35) |
0.583 |
0.94(0.62-1.44) |
0.788 |
|
| CHRT |
41 |
0.74(0.53-1.03) |
0.076 |
0.94(0.67-1.31) |
0.701 |
|
| T stage 1 & 2 |
No |
54 |
1.00 |
|
1.00 |
|
| ERT |
3 |
0.53(0.17-1.70) |
0.284 |
0.56(0.17-1.80) |
0.560 |
|
| CHRT |
3 |
0.24(0.09-0.77) |
0.016 |
0.30(0.09-0.96) |
0.043 |
|
| T stage 3 & 4 |
No |
156 |
1.00 |
|
1.00 |
|
| ERT |
17 |
0.93(0.56-1.52) |
0.761 |
1.01(0.61-1.67) |
0.966 |
|
| CHRT |
32 |
0.87(0.59-1.27) |
0.471 |
1.14(0.77-1.68) |
0.511 |
|
| N0 |
No |
119 |
1.00 |
|
1.00 |
|
| ERT |
14 |
1.03(0.59-1.79) |
0.912 |
1.15(0.66-2.01) |
0.615 |
|
| CHRT |
22 |
0.79(0.50-1.24) |
0.302 |
1.05(0.66-1.67) |
0.838 |
|
| N1 & N2 |
No |
79 |
1.00 |
|
1.00 |
|
| ERT |
7 |
0.75(0.35-1.63) |
0.471 |
0.78(0.36-1.68) |
0.522 |
|
| CHRT |
15 |
0.81(0.47-1.40) |
0.449 |
0.95(0.54-1.67) |
0.860 |
|
| M0 |
No |
181 |
1.00 |
|
1.00 |
|
| ERT |
20 |
0.96(0.61-1.52) |
0.863 |
1.04(0.66-1.66) |
0.861 |
|
| CHRT |
34 |
0.80(0.55-1.15) |
0.232 |
1.03(0.71-1.49) |
0.893 |
|
| M1 | No |
45 |
1.00 |
|
1.00 |
|
| ERT |
4 |
0.78(028–2.16) |
0.632 |
0.77(0.28-2.16) |
0.625 |
|
| CHRT | 7 | 0.66(0.30-1.47) | 0.311 | 0.80(0.36-1.80) | 0.589 |
Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.