Table 4.
Risk of CRC and clinicopathological subgrops in relation to HRT and ERT use in colon and rectum
| |
Colon |
Rectum |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumour subgroups | HRT use | n | HR crude | p | HR adjusted | p | n | HR crude | p | HR adjusted | p |
| CRC |
No |
150 |
1.00 |
|
1.00 |
|
81 |
1.00 |
|
1.00 |
|
| ERT |
15 |
1.21(0.71-2.06) |
0.488 |
1.17(0.67-2.02) |
0.584 |
8 |
0.49(0.23-1.03) |
0.061 |
0.38(0.17-0.86) |
0.020 |
|
| CHRT |
28 |
1.04(0.68-1.57) |
0.873 |
1.16(0.74-1.80) |
0.521 |
13 |
0.44(0.23-0.86) |
0.017 |
0.32(0.14-0.71) |
0.005 |
|
| T stage 1 & 2 |
No |
27 |
1.00 |
|
1.00 |
|
24 |
1.00 |
|
1.00 |
|
| ERT |
1 |
0.52(0.07-3.89) |
0.525 |
0.34(0.04-2.70) |
0.308 |
2 |
0.32(0.07-1.45) |
0.138 |
0.11(0.02-0.67) |
0.017 |
|
| CHRT |
1 |
0.21(0.03-1.54) |
0.125 |
0.24(0.03-1.90) |
0.178 |
2 |
0.09(0.01-0.76) |
0.026 |
0.03(0.00-0.36) |
0.031 |
|
| T stage 3 & 4 |
No |
117 |
1.00 |
|
1.00 |
|
42 |
1.00 |
|
1.00 |
|
| ERT |
13 |
1.29(0.73-2.30) |
0.381 |
1.30(0.72-2.35) |
0.384 |
4 |
0.53(0.19-1.48) |
0.223 |
0.51(0.17-1.55) |
0.233 |
|
| CHRT |
24 |
1.17(0.75-1.83) |
0.486 |
1.27(0.78-2.04) |
0.335 |
8 |
0.72(0.33-1.58) |
0.414 |
0.74(0.28-1.94) |
0.533 |
|
| N0 |
No |
72 |
1.00 |
|
1.00 |
|
45 |
1.00 |
|
1.00 |
|
| ERT |
11 |
1.72(0.91-3.26) |
0.096 |
1.54(0.79-3.00) |
0.203 |
3 |
0.36(0.11-1.20) |
0.097 |
0.31(0.08-1.13) |
0.076 |
|
| CHRT |
16 |
1.20(0.70-2.08) |
0.508 |
1.49(0.83-2.67) |
0.183 |
6 |
0.29(0.10-0.85) |
0.024 |
0.22(0.06-0.77) |
0.222 |
|
| N1 & N2 |
No |
64 |
1.00 |
|
1.00 |
|
18 |
1.00 |
|
1.00 |
|
| ERT |
4 |
0.76(0.28-2.10) |
0.596 |
0.79(0.28-2.23) |
0.659 |
3 |
1.03(0.30-3.56) |
0.959 |
1.00(0.26-3.92) |
1.000 |
|
| CHRT |
10 |
0.90(0.46-1.77) |
0.762 |
0.79(0.37-1.65) |
0.522 |
5 |
1.18(0.42-3.34) |
0.757 |
1.00(0.27-3.73) |
1.000 |
|
| M0 |
No |
114 |
1.00 |
|
1.00 |
|
64 |
1.00 |
|
1.00 |
|
| ERT |
13 |
1.38(0.77-2.46) |
0.277 |
1.25(0.69-2.26) |
0.471 |
7 |
0.54(0.24-1.20) |
0.130 |
0.43(0.18-1.03) |
0.057 |
|
| CHRT |
22 |
1.10(0.69-1.74) |
0.695 |
1.21(0.74-1.97) |
0.446 |
12 |
0.54(0.29-1.09) |
0.084 |
0.42(0.18-0.98) |
0.044 |
|
| M1 | No |
32 |
1.00 |
|
1.00 |
|
13 |
1.00 |
|
1.00 |
|
| ERT |
3 |
1.04(0.32-3.40) |
0.953 |
1.24(0.37-4.16) |
0.732 |
1 |
0.31(0.04-2.48) |
0.269 |
0.32(0.03-3.24) |
0.335 |
|
| CHRT | 6 | 1.06(0.44-2.56) | 0.900 | 1.13(0.42-3.00) | 0.809 | 1 | 0.14(0.02-1.22) | 0.075 | 0.06(0.00-1.18) | 0.064 | |
Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.