Table 5.
Risk of CRC and molecular subgroups in relation to HRT and ERT use in colon and rectum
| |
Colon |
Rectum |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumour subgroups | HRT use | n | HR crude | p | HR adjusted | p | n | HR crude | p | HR adjusted | p |
| beta-catenin + |
No |
68 |
1.00 |
|
1.00 |
|
51 |
1.00 |
|
1.00 |
|
| ERT |
9 |
1.62(0.80-3.26) |
0.180 |
1.52(0.74-3.16) |
0.257 |
4 |
0.38(0.14-1.09) |
0.073 |
1.00(0.45-2.25) |
1.000 |
|
| CHRT |
11 |
0.88(0.46-1.67) |
0.696 |
0.96(0.48-1.91) |
0.910 |
8 |
0.44(0.19-1.02) |
0.054 |
1.00(0.44-2.26) |
1.000 |
|
| beta-catenin − |
No |
64 |
1.00 |
|
1.00 |
|
17 |
1.00 |
|
1.00 |
|
| ERT |
4 |
0.76(0.27-2.09) |
0.588 |
0.71(0.25-1.97) |
0.506 |
3 |
0.87(0.24-3.12) |
0.833 |
1.00(0.27-3.73) |
1.000 |
|
| CHRT |
10 |
0.91(0.46-1.78) |
0.779 |
0.92(0.45-1.88) |
0.808 |
3 |
0.41(0.09-1.83) |
0.242 |
1.00(0.25-3.95) |
1.000 |
|
| cyclin D1 + |
No |
120 |
1.00 |
|
1.00 |
|
50 |
1.00 |
|
1.00 |
|
| ERT |
10 |
1.04(0.54-1.98) |
0.917 |
0.96(0.49-1.86) |
0.895 |
6 |
0.56(0.23-1.34) |
0.189 |
0.44(0.17-1.14) |
0.091 |
|
| CHRT |
18 |
0.86(0.52-1.42) |
0.557 |
0.95(0.56-1.62) |
0.854 |
11 |
0.60(0.28-1.28) |
0.188 |
0.51(0.21-1.24) |
0.135 |
|
| cyclin D1 − |
No |
15 |
1.00 |
|
1.00 |
|
16 |
1.00 |
|
1.00 |
|
| ERT |
3 |
2.05(0.59-7.10) |
0.260 |
2.34(0.65-8.44) |
0.196 |
1 |
0.37(0.05-2.81) |
0.334 |
0.28(0.03-2.27) |
0.232 |
|
| CHRT |
4 |
1.33(0.44-4.05) |
0.615 |
1.50(0.46-4.94) |
0.504 |
1 |
0.19(0.02-1.56) |
0.124 |
0.07(0.01-0.88) |
0.039 |
|
| p53 + |
No |
54 |
1.00 |
|
1.00 |
|
40 |
1.00 |
|
1.00 |
|
| ERT |
6 |
1.38(0.59-3.24) |
0.454 |
1.27(0.53-3.02) |
0.588 |
5 |
0.54(0.21-1.41) |
0.208 |
1.00(0.43-2.35) |
1.000 |
|
| CHRT |
9 |
0.94(0.46-1.92) |
0.869 |
1.02(0.48-2.20) |
0.951 |
9 |
0.56(0.25-1.27) |
0.168 |
1.00(0.42-2.40) |
1.000 |
|
| p53 − |
No |
82 |
1.00 |
|
1.00 |
|
26 |
1.00 |
|
1.00 |
|
| ERT |
7 |
1.02(0.47-2.21) |
0.968 |
0.95(0.43-2.11) |
0.903 |
2 |
0.47(0.11-2.02) |
0.308 |
0.23(0.05-1.18) |
0.078 |
|
| CHRT |
13 |
0.89(0.49-1.61) |
0.703 |
1.00(0.54-1.86) |
0.996 |
3 |
0.36(0.09-1.54) |
0.170 |
0.19(0.04-0.96) |
0.044 |
|
| MSI |
No |
36 |
1.00 |
|
1.00 |
|
2 |
1.00 |
|
1.00 |
|
| ERT |
1 |
0.36(0.05-2.67) |
0.320 |
0.28(0.04-2.08) |
0.212 |
0 |
- |
|
- |
|
|
| CHRT |
5 |
0.84(0.32-2.16) |
0.710 |
0.90(0.34-2.40) |
0.832 |
0 |
- |
|
- |
|
|
| MSS |
No |
97 |
1.00 |
|
1.00 |
|
64 |
1.00 |
|
1.00 |
|
| ERT |
11 |
1.35(0.72-2.53) |
0.349 |
1.36(0.71-2.60) |
0.352 |
7 |
0.54(0.24-1.22) |
0.138 |
1.00(0.49-2.03) |
1.000 |
|
| CHRT | 17 | 0.98(0.58-1.65) | 0.943 | 1.08(0.62-1.89) | 0.789 | 11 | 0.46(0.22-0.97) | 0.041 | 1.00(0.49-2.05) | 1.000 | |
Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.