Table 7.
Risk of colorectal cancer, overall and according to clinicopathological factors, in relation to oral contraceptive (OC) use in colon and rectum
| |
Colon |
Rectum |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumour subgroups | OC use | n | HR crude | p | HR adjusted | p | n | HR crude | p | HR adjusted | p |
| CRC |
No |
116 |
1.00 |
|
1.00 |
|
69 |
1.00 |
|
1.00 |
|
| OC |
59 |
1.00(0.73-1.37) |
0.998 |
1.41(0.96-2.08) |
0.080 |
37 |
1.02(0.68-1.53) |
0.934 |
0.97(0.59-1.60) |
0.900 |
|
| T stage 1&2 |
No |
22 |
1.00 |
|
1.00 |
|
21 |
1.00 |
|
1.00 |
|
| OC |
8 |
0.72(0.32-1.62) |
0.422 |
1.43(0.56-3.66) |
0.462 |
8 |
0.76(0.33-1.76) |
0.521 |
0.67(0.23-1.89) |
0.445 |
|
| T stage 3 &4 |
No |
89 |
1.00 |
|
1.00 |
|
34 |
1.00 |
|
1.00 |
|
| OC |
49 |
1.08(0.76-1.54) |
0.655 |
1.43(0.93-2.22) |
0.107 |
24 |
1.22(0.72-2.07) |
0.460 |
1.27(0.64-2.53) |
0.488 |
|
| N0 |
No |
63 |
1.00 |
|
1.00 |
|
37 |
1.00 |
|
1.00 |
|
| OC |
26 |
0.77(0.49-1.22) |
0.271 |
1.17(0.67-2.03) |
0.582 |
18 |
0.93(0.52-1.66) |
0.811 |
0.90(0.43-1.88) |
0.780 |
|
| N1 & N2 |
No |
43 |
1.00 |
|
1.00 |
|
17 |
1.00 |
|
1.00 |
|
| OC |
30 |
1.38(0.86-2.20) |
0.181 |
1.81(1.00-3.28) |
0.051 |
12 |
1.20(0.57-2.52) |
0.630 |
1.00(0.39-2.56) |
1.000 |
|
| M0 |
No |
88 |
1.00 |
|
1.00 |
|
57 |
1.00 |
|
1.00 |
|
| OC |
47 |
1.05(0.73-1.49) |
0.804 |
1.55(1.00-2.40) |
0.050 |
31 |
1.00(0.64-1.56) |
0.999 |
0.83(0.47-1.45) |
0.507 |
|
| M1 |
No |
26 |
1.00 |
|
1.00 |
|
9 |
1.00 |
|
1.00 |
|
| OC |
12 |
0.90(0.45-1.80) |
0.771 |
0.96(0.41-2.30) |
0.955 |
5 |
1.09(0.35-3.36) |
0.880 |
1.75(0.44-6.86) |
0.425 |
|
| beta-catenin+ |
No |
56 |
1.00 |
|
1.00 |
|
43 |
1.00 |
|
1.00 |
|
| OC |
24 |
0.84(0.52-1.37) |
0.489 |
1.36(0.75-2.47) |
0.308 |
24 |
1.02(0.62-1.70) |
0.931 |
1.00(0.53-1.88) |
1.000 |
|
| beta-catenin− |
No |
45 |
1.00 |
|
1.00 |
|
14 |
1.00 |
|
1.00 |
|
| OC |
29 |
1.27(0.79-2.03) |
0.322 |
1.70(0.97-3.00) |
0.065 |
10 |
1.41(0.61-3.24) |
0.421 |
1.00(0.35-2.87) |
1.000 |
|
| cyclin D1+ |
No |
88 |
1.00 |
|
1.00 |
|
44 |
1.00 |
|
1.00 |
|
| OC |
46 |
1.04(0.72-1.47) |
0.843 |
1.62(1.04-2.51) |
0.032 |
24 |
1.06(0.64-1.76) |
0.826 |
1.04(0.56-1.95) |
0.893 |
|
| cyclin D1− |
No |
15 |
1.00 |
|
1.00 |
|
14 |
1.00 |
|
1.00 |
|
| OC |
8 |
1.00(0.42-2.36) |
0.999 |
0.90(0.31-2.60) |
0.844 |
7 |
0.82(0.33-2.03) |
0.666 |
0.77(0.24-2.48) |
0.660 |
|
| p53+ |
No |
45 |
1.00 |
|
1.00 |
|
32 |
1.00 |
|
1.00 |
|
| OC |
20 |
0.90(0.52-1.53) |
0.685 |
1.28(0.67-2.45) |
0.451 |
22 |
1.37(0.78-2.39) |
0.274 |
1.00(0.49-2.02) |
1.000 |
|
| p53− |
No |
59 |
1.00 |
|
1.00 |
|
26 |
1.00 |
|
1.00 |
|
| OC |
34 |
1.11(0.73-1.70) |
0.625 |
1.54(0.90-2.63) |
0.115 |
9 |
0.59(0.28-1.27) |
0.177 |
0.52(0.21-1.30) |
0.161 |
|
| MSI |
No |
25 |
1.00 |
|
1.00 |
|
2 |
1.00 |
|
1.00 |
|
| OC |
14 |
1.08(0.56-2.09) |
0.809 |
1.85(0.82-1.18) |
0.139 |
0 |
- |
|
- |
|
|
| MSS |
No |
76 |
1.00 |
|
1.00 |
|
54 |
1.00 |
|
1.00 |
1.000 |
| OC | 39 | 1.02(0.69-1.50) | 0.938 | 1.43(0.89-2.32) | 0.143 | 32 | 1.10(0.70-1.72) | 0.678 | 1.00(0.58-1.74) | ||
Adjusted for age, bmi, educational level, smoking habits and alcohol consumption.