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. 2014 May 6;11:85. doi: 10.1186/1742-2094-11-85

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Copyright © 2014 Vasconcelos et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Intermittent fasting (IF) inhibits lipopolysaccharide LPS)-induced increases in inflammatory mediators in the hippocampus and serum. Levels of hippocampal IL-1α (A), IL-1β (B), TNF-α (C), IL-10 (D) and RANTES (E), and levels of serum IL-1β (F), TNF-α (G), IL-6 (H), RANTES (I) and IFN-γ (J) were measured by multiplex or ELISA (*P < 0.05 versus Control; **P < 0.01 versus Control; ***P < 0.001 versus Control; #P < 0.05 versus LPS; ##P < 0.01 versus LPS and ###P < 0.001 versus LPS. N = 5 to 10 for each experimental group.