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Fibrin deposition precedes demyelination and correlates with demyelinating plaques in TgK21 mice. Immunohistochemistry for fibrin(ogen) shows deposition of fibrin (A) at areas of meningeal inflammation before the onset of demyelination (B). In addition, fibrin immunoreactivity (C) is detected at areas the spinal cord associated with inflammation and loss of myelin (D). A and C and B and D represent high-magnification images of Fig. 1 D and B, respectively. (Bar = 125 μm.)
