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. Author manuscript; available in PMC: 2014 Jun 2.
Published in final edited form as: Brain Res. 2013 May 31;1523:49–58. doi: 10.1016/j.brainres.2013.05.040

Fig. 3.

Fig. 3

Region- and gene- specific effects of heroin on levels of GABA receptor subunit mRNAs in 129P3/J mice. In the SN/VTA, there were significant main effects of Dose on expression levels of (A) GABA-Aα1 mRNA (F(5,51) =5.73, p<0.0005), and (B) GABA-Aα4 mRNA (F(5,51) =3.20, p<0.05). In the NAc, there were significant main effects of Dose on expression levels of (C) GABA-Aα1 mRNA (F(5,52) =8.194, p<0.00001), (D) GABA-Aα3 mRNA (F(5,60) =5.72, p<0.0005), (E) GABA-Aδ mRNA (F(5,60) =2.94, p<0.05), and (F) GABA-BR2 mRNA (F(5,58) =4.499, p<0.005). In the CPu, there was a significant main effect of Dose on expression levels of (G) GABA-Aδ mRNA (F(5,45) =7.13, p<0.0001), and in the cortex there was a significant main effect of Dose on expression levels of (H) GABA-Aα3 mRNA (F(5,58) =3.55, p<0.01). Lines marked with asterisks are used to illustrate significant differences, according to the Newman–Keuls post hoc test.