Table 1. Effects of carbenoxolone or placebo on plasma electrolytes, cortisol, and blood pressure in two distinct, randomized, double-blind, placebo-controlled crossover studies in healthy elderly subjects and patients with stable type 2 diabetes.
| Healthy elderly subjects
|
Patients with type 2 diabetes
|
|||||
|---|---|---|---|---|---|---|
| Placebo with amiloride mean (SD) | Carbenoxolone with amiloride mean (SD) | P | Placebo with amiloride mean (SD) | Carbenoxolone with amiloride mean (SD) | P | |
| Plasma Na (mmol/liter) | 141 (2) | 142 (2) | 0.054 | 139 (3) | 139 (3) | 0.46 |
| Plasma K (mmol/liter) | 4.37 (0.34) | 4.34 (0.37) | 0.82 | 4.44 (0.41) | 4.58 (0.32) | 0.03* |
| 9:00 a.m. plasma cortisol (μg/dl) | 15.3 (9.2) | 15.6 (8.2) | 0.94 | 20.7 (7.3) | 22.7 (7.3) | 0.51 |
| Systolic blood pressure (mmHg) | 123 (14) | 123 (14) | 0.84 | 133 (14) | 133 (14) | 1.00 |
| Diastolic blood pressure (mmHg) | 70 (9) | 71 (8) | 0.12 | 78 (6) | 78 (6) | 1.00 |
*
, P < 0.05 compared with placebo.