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Effects of ABT-724 and prazosin on mean arterial pressure (Upper) and hindquarter vascular resistance (Lower) in rats. Drugs were administered i.v. over a 30-min infusion for each dosing (n = 5 for ABT-724 and n = 7 for prazosin). Values collected from the last 5-min time point of infusion are presented as mean ± SEM of hemodynamic changes from drug predosing. Data were analyzed by unpaired t test. *, P < 0.05 compared to the baseline of drug predosing.
