Table 4. Effect of ABT-724 and PNU-95666E in male ferrets after s.c. injection.
| Emesis, % incidence | Emetic episodes | Latency to vomit | |
|---|---|---|---|
| Vehicle | 0 | 0 | - |
| ABT-724 0.03 μmol/kg | 0 | 0 | - |
| ABT-724 0.3 μmol/kg | 0 | 0 | - |
| ABT-724 3 μmol/kg | 0 | 0 | - |
| PNU-95666E 0.1 μmol/kg | 0 | 0 | - |
| PNU-95666E 0.3 μmol/kg | 0 | 0 | - |
| PNU-95666E 1 μmol/kg | 83.3 | 3.8 ± 0.7 | 8.1 ± 1.6 |
| PNU-95666E 3 μmol/kg | 100 | 5.2 ± 1.1 | 8.0 ± 2.6 |
Data are expressed as the percentage of ferrets exhibiting emesis, the mean ± SEM number of emetic episodes, and the mean ± SEM latency to vomit in minutes. Six ferrets were included in each group.